Hematopoietic stem cells

The FDA ( U.S. Food and Drug Administration ) has approved Abecma ( Idecabtagene vicleucel; Ide-cel ) as the first...


The FDA ( U.S. Food and Drug Administration ) has approved Onureg ( Azacitidine 300 mg tablets, CC-486 ) for...


The European Commission ( EC ) has approved Empliciti ( Elotuzumab ) plus Pomalidomide and low-dose Dexamethasone ( EPd )...


Acute myeloid leukemia ( AML ) remains a highly resistant disease to conventional chemotherapy, with a median survival of only...



The FDA ( U.S. Food and Drug Administration ) has approved Keytruda ( Pembrolizumab ), an anti-PD-1 therapy, in combination...


Aging is associated with an increased incidence of cancer and cardiovascular disease. Researchers recently used whole-exome sequencing data to identify...


The FDA ( U.S. Food and Drug Administration ) has approved Keytruda ( Pembrolizumab ), the anti-PD-1 ( programmed death...


Although most patients with relapsed B-cell acute lymphoblastic leukemia ( B-ALL ) experienced complete response after treatment with a type...


A major clinical trial led by researchers at Dana-Farber Cancer Institute and Brigham and Women’s Hospital ( BWH ) has...


The European Commission has approved Empliciti ( Elotuzumab ) for the treatment of multiple myeloma as combination therapy with Revlimid...


Positive results from the global phase III RATIFY ( CALGB 10603 ) clinical trial were announced. In the study, adult...


The European Commission ( EC ) has approved Revolade ( Eltrombopag ) for the treatment of adult patients with severe...


Synovial joint damage is mediated by cells of the pannus. In rheumatoid arthritis, there is a marked increase in proliferation,...


The Food and Drug Administration ( FDA ) has approved a supplemental New Drug Application ( sNDA ) for the...



In humans, mutations in the gene encoding for forkhead box P3 ( FOXP3 ), a critically important transcription factor for...


Gene therapy of inherited diseases has provided convincing evidence of therapeutic benefits for many treated patients. In particular, treatment of...


Recessive dystrophic epidermolysis bullosa ( RDEB ) results from deficiency of type VII collagen ( C7 ), which results in...


Pyruvate kinase deficiency ( PKD ) is a monogenic metabolic disease caused by mutations in the PKLR gene that impairs...