ASSESS trial: efficacy and safety of Fingolimod 0.5 mg and 0.25 mg versus Glatiramer acetate 20 mg in patients with relapsing-remitting multiple sclerosis
The aim of the study was to evaluate whether Fingolimod [ Gilenya ] ( 0.5 mg and 0.25 mg )...
Natalizumab ( Tysabri ), a humanized monoclonal antibody, was approved by the Food and Drug Administration ( FDA ) in...
Gilenya: FDA warns about cases of progressive multifocal leukoencephalopathy in patients with multiple sclerosis
The FDA ( Food and Drug Administration ) warned that a case of definite progressive multifocal leukoencephalopathy ( PML )...
Multiple sclerosis ( MS ) is a chronic disabling disease of the central nervous system ( CNS ), affecting more...
The lack of prospective trial data comparing certain multiple sclerosis therapies could be addressed with observational research. Researchers have investigated outcomes...
Multiple sclerosis: Gilenya reduced relapse rates, new MRI lesion counts, brain volume loss and disability progression in previously-treated patients with high disease activity
New analyses of pooled data from the FREEDOMS and FREEDOMS II trials have shown the consistent efficacy of Gilenya (...
Fingolimod in relapsing-remitting multiple sclerosis: beneficial effects on relapse rates, but no effect on disability progression
Fingolimod ( Gilenya ) has shown reductions in clinical and MRI disease activity in patients with relapsing-remitting multiple sclerosis. The...
Previous therapeutic strategies for multiple sclerosis ( MS ) include the non-selective suppression of systemic immunity ( immunosuppressive agents, such...
Gilenya: bradycardia and heart block; repeat enhanced cardiovascular monitoring when restarting the medicine after treatment interruption
Starting Fingolimod ( Gilenya ) treatment, or re-starting Fingolimod after treatment interruption, results in transient decreases in heart rate. In...
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