Apoptosis

The FDA ( Food and Drug Administration ) has accepted the New Drug Application ( NDA ) and granted Priority...


Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs...


Detailed results from an open-label phase 2 trial evaluating the investigational apoptosis signal-regulating kinase 1 ( ASK1 ) inhibitor Selonsertib...


With few treatment options available to patients with advanced bladder cancer, investigators are looking for novel molecular targets. In a...


Preclinical urothelial carcinoma models suggest activity of Dasatinib ( Sprycel ), an oral Src-family kinase ( SFK ) inhibitor. Researchers...


The FDA ( Food and Drug Administration ) has granted a Breakthrough Therapy Designation to the immunotherapy Darzalex ( Daratumumab...


EGFR belongs to the ErbB family of transmembrane tyrosine kinase receptors ( ErbB comprises ErbB1/EGFR/HER1, ErbB2/HER2/NEU, ErbB3/HER3, and ErbB4/HER4 )....


A phase 2 trial of the investigational medicine Venetoclax met its primary endpoint ( overall response rates ) in patients...


The CHER-LOB randomized phase II study showed that the combination of Lapatinib ( Tyverb ) and Trastuzumab ( Herceptin )...


Results of a phase 2 open-label, single-arm, multicenter trial to evaluate the efficacy and safety of Blinatumomab ( Blincyto )...


Increasing evidences link T helper 17 ( Th17 ) cells with multiple sclerosis ( MS ). In this context, interleukin-22...


Acute myeloid leukaemia ( AML ) is an aggressive and devastating blood cancer. It predominantly affects people over 60 and...


Results from a phase II study, published in the American Society of Hematology journal Blood, showed patients with previously untreated...



Researchers at Sanford-Burnham Medical Research Institute ( Orlando, Florida; United States ) have identified a set of RNA molecules that...


The use of non-invasive imaging to identify ruptured or high-risk coronary atherosclerotic plaques would represent a major clinical advance for...


A phase-I study for patients with chronic lymphocytic leukaemia has shown promising results. Chronic lymphocytic leukaemia ( CLL ) is...


Nonviral gene therapy represents a realistic option for clinical application in cancer treatment. A preclinical study has demonstrated the advantage...


Researchers have developed a novel strategy for treatment of Leber hereditary optic neuropathy ( LHON ) caused by a mutation...


In Canada, Docetaxel ( Taxotere ) is an injectable chemotherapy drug that was first marketed on December 31, 1995. It...