Antiviral therapy

Although direct-acting antiviral ( DAA ) therapies for chronic hepatitis C virus ( HCV ) infection have demonstrated high rates...


In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say...


Revolade ( Eltrombopag ) is used in adults for the treatment of: • long-term immune thrombocytopenic purpura ( ITP ), a...


A study has evaluated the clinical outcomes of Telaprevir- or Simeprevir-based triple therapy for recurrent hepatitis C after living donor...


Favourable efficacy and safety profiles for Simeprevir ( Olysio ) in combination with Pegylated interferon alpha ( PEG-IFN alpha )...


Herpes zoster is common and vaccine preventable. Stroke risk may be increased following zoster, but evidence is sparse and could...


Interferon-containing regimens for the treatment of hepatitis C virus ( HCV ) infection are associated with increased toxic effects in...


Results from studies in chronic hepatitis C patients with human immunodeficiency virus type 1 ( HIV-1 ) co-infection ( TURQUOISE-I...


Hepatitis C virus ( HCV ) infects more than 185 million individuals worldwide. Twenty percent of patients chronically infected with...


Interferon-containing regimens for the treatment of hepatitis C virus ( HCV ) infection are associated with increased toxic effects in...


In clinical trials, treatment with a combination of the nucleotide polymerase inhibitor Sofosbuvir ( Sovaldi ) and the antiviral drug...


Eltrombopag ( United States: Promacta; Europe: Revolade ), in addition to the approval for severe aplastic anemia in the U.S.,...


An Interferon-free combination of the protease inhibitor ABT-450 with Ritonavir ( ABT-450/r ), the nonnucleoside polymerase inhibitor ABT-333, and Ribavirin...


Idenix Pharmaceuticals has announced interim data from the ongoing phase II 12-week HELIX-1 clinical trial evaluating an all-oral, direct-acting antiviral...


Maraviroc ( Celsentri, Selzentry ), a chemokine co-receptor type 5 ( CCR5 ) antagonist, has demonstrated comparable efficacy and safety...


ZMapp is an experimental treatment, developed by Mapp Biopharmaceutical, for use with individuals infected with Ebola virus. It has not...


Results from RESTORE , a phase III, multicentre, single-arm, open-label study presented at the International Liver Congress 2014 showed that...


The FDA ( Food and Drug Administration ) has approved Olysio ( Simeprevir ), an NS3/4A protease inhibitor, for the...


The approval of two hepatitis C virus ( HCV ) protease inhibitors by the FDA ( Food and Drug Administration...


Improved understanding of HCV replication has allowed for the development of new therapeutic agents that target enzymes directly. HCV is...