Alanine aminotransferase

Although direct-acting antiviral ( DAA ) therapies for chronic hepatitis C virus ( HCV ) infection have demonstrated high rates...


Data from the pivotal phase 3 LATITUDE clinical trial showed Abiraterone acetate ( Zytiga ) plus Prednisone, in combination with...


The European Medicines Agency's ( EMA ) Committee for Medicinal Products for Human Use ( CHMP ) has adopted a...


Patients with metastatic urothelial carcinoma have few treatment options after failure of Platinum-based chemotherapy. In this trial, researchers have assessed...


Detailed 48-week results from two large phase 3 clinical trials ( Studies 108 and 110 ) evaluating once-daily Tenofovir alafenamide...


The FDA ( Food and Drug Administration ) has approved Zinbryta ( Daclizumab ) for the treatment of adults with...


The FDA ( Food and Drug Administration ) has granted Priority Review for the New Drug Application ( NDA )...


The objective of a study was to evaluate the efficacy and safety of extended dosing with Mipomersen ( Kynamro )...


Blincyto ( Blinatumomab ) is indicated for the treatment of Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia...


Metastatic leiomyosarcomas of uterine or soft-tissue origin have poor prognosis and moderate chemosensitivity. Trabectedin has shown activity in pretreated leiomyosarcoma....


The results of a phase I study in advanced melanoma suggested complementary clinical activity with Nivolumab ( Opdivo ), a...


Vitamin D receptors ( VDR ) bind calcitriol and modulate several physiological systems through genomic and nongenomic pathways. Calcitriol stimulates...


Results from two pivotal studies ( NP28673 and NP28761 ) have showen Alectinib, an oral investigational anaplastic lymphoma kinase inhibitor...


Eltrombopag ( United States: Promacta; Europe: Revolade ), in addition to the approval for severe aplastic anemia in the U.S.,...


Definitive chemoradiotherapy is a curative treatment option for oesophageal carcinoma, especially in patients unsuitable for surgery. The PRODIGE5/ACCORD17 trial aimed...


p38 MAPK inhibition has potential myocardial protective effects. Researchers have assessed Losmapimod, a potent oral p38 MAPK inhibitor, in patients...


Teriflunomide ( Aubagio ) is a once-daily oral immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis. Researchers have assessed the...


Teriflunomide ( Aubagio ) is an oral disease-modifying therapy approved for treatment of relapsing or relapsing–remitting multiple sclerosis. Researchers aimed...


A double-blind, placebo-controlled, dose-finding phase IIb study has evaluated the efficacy and safety of Ponesimod, an oral selective S1P1 receptor...


By inhibiting apolipoprotein B ( ApoB ) synthesis, Mipomersen ( Kynamro ) can significantly reduce ApoB-containing lipoproteins in hypercholesterolemic patients. The...